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Since CD4 + T cell-mediated immunity is required for protection against S. In addition, alpha-toxin has been reported to modulate other cell types including immune cells. One important staphylococcal virulence factor is alpha-toxin, which is able to disrupt the epithelial barrier in order to establish infection. To develop such novel treatment approaches, a better understanding of the bacterial virulence and immune evasion mechanisms and their potential effects on immune-based therapies is essential. Therefore, prophylactic vaccines or immune-based therapies are considered as alternative treatment opportunities. Staphylococcus aureus can cause life-threatening diseases, and hospital- as well as community-associated antibiotic-resistant strains are an emerging global public health problem. 11 Department of Molecular Immunology, Ruhr-University Bochum, Bochum, Germany.10 Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.9 Department Systems-Oriented Immunology and Inflammation Research, Helmholtz Centre for Infection Research, Braunschweig, Germany.8 DZIF, German Center for Infectious Diseases, TTU-IICH Hannover-Braunschweig Site, Hanover, Germany.7 Institute of Transplant Immunology, Hannover Medical School, Hanover, Germany.6 Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hanover, Germany.5 Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research A Joint Venture Between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hanover, Germany.4 Department Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.3 Department of Immunology, University Medicine Greifswald, Greifswald, Germany.2 Department Infection Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
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1 Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.